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| Anti-tumour activity of D-fraction from Maitake mushroom |
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Anti tumor activity of orally administered "D-fraction" from Maitake mushroom (Grifola frondosa)
Journal of Naturopathic Medicine
1993 Vol. 4 No. 1 Pages 10-15
[Abstract:]
It is well known in Japan that some medicinal mushrooms contain polysaccharide compounds, which demonstrate anti tumor activity. The author obtained the acid-insoluble, alkali-soluble, hot water extractable polysaccharide (containing about 30% of protein) "D-fraction" from the fruiting body of the Maitake mushroom, which exhibited anti tumor activity against allogenic and syngeneic tumors on oral administration to mice.
A Winn assay revealed a complete tumor inhibition indicating that stimulation of an immune response triggered by the tumor-bearing state is activated by D-fraction. The cytolytic activity and interleukin-1 productivity of macrophages or T cells, which exhibit antigen-specific cytotoxicity, were enhanced.
Footpad swelling test against D-mice (D-fraction administered tumor-bearing mice) suggested that delayed type hypersensitivity (DTH) reaction against tumor antigen was potentiated. Winn assay was carried out with whole spleen cells from D-mice and Lyt-2 spleen cells in which Lyt-2 cells corresponding to cytotoxic T cells (CTL) were eliminated by treating with anti-Lyt-2 monoclonal antibody and complement. It confirmed that tumor neutralizing activity was at no time impaired even after CTL were eliminated, concluding that a DTH reaction, manifested by the combined action of delayed hypersensitivity T cells (T dh) and macrophages was potentiated by oral administration of D-fraction.
The above information is provided for general
educational purposes only. It is not intended to replace competent
health care advice received from a knowledgeable healthcare professional.
You are urged to seek healthcare advice for the treatment of any
illness or disease.
Health Canada and the FDA (USA) have not evaluated these
statements. This product is not intended to diagnose, treat, cure, or prevent
any disease.
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15 or 30 sachets per box
$45 or $85 per box
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