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| 100% Pure Antarctic Krill Oil |
| Astaxanthin - powerful antioxidant |
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| Anti-tumour activity of D-fraction from Maitake mushroom |
| Maitake D-fraction inhibit carcinogenesis and metastasis |
| Sparassis crispa mushroom SCG 1,3-beta-D-glucan effect on luokopenic mice |
| Functional properties of edible mushrooms |
| Maitake mushroom effects on liver serums and lipids |
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Effect of SCG 1,3-beta-D-glucan from Sparassis
Crispa on hematopoietic response in cyclophosphamide induced leukopenic mice
Harada T, Miura N, Adachi Y, Yadomae T, Ohn N
Laboratory of Immunopharmacology
Microbial Products School of Pharmacy, Tokyo University, Hachioji Japan
[Abstract:]
Sparassis crispa Fr. is an edible mushroom recently cultivable in Japan. It contains a remarkably high content of 6-branched 1,3-beta-D-glucan showing antitumor activity.
Using ion-exchange chromatography, a purified beta-glucan preparation, SCG, was prepared. In this study, we examined the hematopoietic response by SCG in cyclophosphamide (CY)-induced leukopenic mice. SCG enhanced the hematopoietic response in CY induced leukopenic mice by intraperitoneal routes over a wide range of concentrations. SCG enhanced the hematopoietic response in CY-treated mice by prior or post administration.
Analyzing the leukocyte population by flow cytometry, monocytes and granulocytes in the peritoneal cavity, liver, spleen and bone marrow (BM) recovered faster than in the control group. The ratio of natural killer cells and gammadelta T cells in the liver, spleen and peritoneal cavity was also increased. In contrast, CD4+ CD8+ cells in the thymus were temporarily significantly decreased by the administration of SCG. Interleukin-6 (IL-6) production of CY+SCG-treated peritoneal exdated cells (PECs), spleen cells and bone marrow cells (BMCs) were higher than that of the CY-treated group. By in vitro culture of CY-treated PEC and spleen cells, IL-6 production was enhanced by the addition of SCG.
These facts suggested the possibility that IL-6 might be a key cytokine for the enhanced
hematopoietic response by SCG.
The above information is provided for general
educational purposes only. It is not intended to replace competent
health care advice received from a knowledgeable healthcare professional.
You are urged to seek healthcare advice for the treatment of any
illness or disease.
Health Canada and the FDA (USA) have not evaluated these
statements. This product is not intended to diagnose, treat, cure, or prevent
any disease.
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15 or 30 sachets per box
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